Table 1.
Immune cells and Sjögren's syndrome mouse model.
| Classification | Mouse model | Phenotype | |
|---|---|---|---|
| Immune cells | Epithelial cells of salivary glands | Treatment of NFS/Sld mouse model with anti-CD86 antibody | Salivary adenitis, reduced lacrimal adenitis |
| TLR8ko mice | Salivary adenitis, autoantibodies | ||
| B lymphocytes | C3H/HeJ mice immunized with peptide Ro60-316-335 | Lacrimal adenitis, autoantibodies | |
| C57BL/6.NOD-Aec1Aec2 mice | Salivary adenitis, lymphocytic infiltration | ||
| T lymphocytes | Aly/Aly spontaneous mouse model | Lymphocytic infiltration | |
| STAB1ko mice | Reduced salivary secretion, infiltration of T lymphocytes in salivary glands, autoantibodies | ||
| RoRrt transgenic mouse model | Salivary adenitis | ||
| Th17-treated IL-17KO mouse model | Reduced salivary secretion, exocrine adenitis, autoantibodies | ||
| Dendritic cells | NOD mouse model | DC infiltration of submandibular gland | |