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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Biochim Biophys Acta Proteins Proteom. 2021 Jun 3;1869(9):140679. doi: 10.1016/j.bbapap.2021.140679

Figure 4. Location of the Q site in the overall structure showing two modes of binding.

Figure 4.

Panel A shows an enlarged view around the Q site in the same orientation as in Figure 1, with AA5 bound (pdb 6MYS). B shows a further enlargement with key side chains labeled, and C is the same rotated about 90° about the vertical to give a side view of the inhibitor. D and E are the same view as B and C but with thiapronil (TPR) bound (pdb 6MYR) instead of AA5. While the long side chain (“tail”) of AA5 hangs out into the lipid/detergent milieu, that of thiapronil inserts into a pocket between three residues of SdhC. In C and E, TMH2 of SdhD has been removed to expose the site, leaving the sidechains of residues D57 and Y58 unattached. Stereo views of these scenes are available in the supplementary materials.