Table 4.

Plasma and epithelial lining fluid concentrations of ketolides

Antibacterial agent	Dosage regimen	Subjects [n]	Sampling time [h]a	ELF to plasma ratio based on AUC	Plasma concentration [µg/mL]b	ELF concentration [µg/mL]b	References
Solithromycin	400 mg PO q24h × 5 days	6	3	10.3c	0.730 ± 0.692	7.58 ± 6.69	[62]
		6	6		0.595 ± 0.325	6.50 ± 2.73
		6	9		0.301 ± 0.185	3.78 ± 4.32
		6	12		0.300 ± 0.171	2.54 ± 2.55
		6	24		0.086 ± 0.070	1.02 ± 0.83
Nafithromycin	800 mg PO q24h × 3 doses	6	3	13.8c	1.105 ± 0.140	18.48 ± 12.31	[66]
		6	6		0.966 ± 0.439	15.29 ± 14.53
		6	9		0.922 ± 0.286	8.37 ± 4.38
		5	12		0.817 ± 0.261	9.67 ± 6.20
		6	24		0.239 ± 0.055	4.13 ± 1.38
		6	48		0.060 ± 0.029	1.62 ± 0.86

ELF epithelial lining fluid, AUC area under the concentration-time curve, PO by mouth, qxh every x hours, SD standard deviation

^aSampling time after the last dose

^bTotal plasma and ELF concentrations expressed as mean ± SD

^cBased on the ratio of AUC₂₄ in ELF to AUC₂₄ in total plasma