Table 3.

Bivariable analyses for all-grade VAHL and grade 3–4 VAHL

Variable 1	Variable 2	All grade VAHL			Grade 3–4 VAHL
		Pv	OR	95% CI	Pv	OR	95% CI
		(Numbers refer to variable 2)			(Numbers refer to variable 2)
Interval between vaccination and imaging (days)	Gender (female)	0.10	1.91	0.89–4.11	0.31	1.85	0.57–6.06
	Age (years)	0.01*	0.93	0.89–0.98	0.01*	0.92	0.86–0.98
	BMI (kg/m2)	0.08	1.01	0.99–1.17	0.10	0.88	0.76–1.03
	Hematologic malignancies	0.41	0.64	0.23–1.83	0.42	0.40	0.04–3.77
	Lower gastrointestinal cancers	0.58	0.74	0.26–2.10	0.72	0.74	0.14–3.96
	Breast cancer	0.83	1.12	0.39–3.25	0.38	0.37	0.04–3.29
	Lung cancers	0.90	1.07	0.36–3.22	0.62	0.65	0.12–3.56
	Skin cancers and sarcomas	0.15	0.40	0.11–1.39	0.43	0.41	0.04–3.79
	Hepatobiliary-pancreatic cancers	0.23	2.29	0.59–8.93	0.08	4.80	0.84–27.32
	Gynecological cancers	0.23	2.67	0.53–13.33	0.58	1.77	0.23–13.59
	Genitourinary cancers	0.94	0.94	0.19–4.58	0.99	-	-
	Upper gastrointestinal cancers	0.94	1.07	0.18–6.32	0.14	5.30	0.58–48.46
	Head and neck cancers	0.65	1.89	0.12–30.54	0.15	8.69	0.46–162.69
	Active malignancy	0.50	0.74	0.31–1.77	0.46	1.72	0.41–7.26
	Recent systemic anti-cancer therapy	0.30	0.66	0.30–1.45	0.43	1.59	0.50–5.04
	Recent chemotherapy	0.77	0.87	0.35–2.18	0.22	2.12	0.65–6.91
	Recent biologic therapy	0.41	0.68	0.27–1.71	0.78	0.81	0.19–3.46
	Recent immunotherapy	0.57	0.64	0.14–2.92	0.26	2.91	0.45–18.80

Each parameter was analyzed together with the time interval between vaccination and imaging on a bivariable logistic regression. Analyses were performed for the prediction of all-grade VAHL and grade 3–4 VAHL. The odds ratio (OR) with 95% confidence interval (CI) for each analyzed variable are presented for the prediction of all-grade VAHL and grade 3–4 VAHL. VAHL, vaccine-associated hypermetabolic lymphadenopathy; BMI, body mass index. Active malignancy, this variable was considered positive in cases of treatment-naïve patients, those who received recent anti-cancer therapy, and those with recurrent disease identified on their [¹⁸F]FDG PET-CT scan. Recent therapy was considered if given during the 3 months before the scan