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. 2021 Oct 7;27(10):1718–1724. doi: 10.1038/s41591-021-01509-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — Glycan signatures are displayed for participants with (a) high viral load and sensitive viruses at baseline, (b) high viral load and resistant viruses at baseline, and (c) low viral load at baseline. LOGO plots are shown representing the sensitivity and resistance mutations for all V3 glycan signatures. The height of the letter indicates the frequences the sample, for the baseline on the top, and the post PGT121 treatment directly underneath. The putative resistance conferring mutations are boxed in black. Red letters indicate resistance, blue sensitivity, green depended on the antibody, and black indicate amino acids not supported statistically as either a sensistivity or resistance signature. The signatures outside of the binding region are more likely to modulate levels of sensitivity, and are seldom perturbed.