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. 2021 Oct 7;27(10):1718–1724. doi: 10.1038/s41591-021-01509-0

Extended Data Fig. 9. Immunologic responses following PGT121 infusion in HIV-infected participants on ART.

Extended Data Fig. 9

The number of IFN-γ secreting CD4 + and CD8 + T cells (A and B, respectively), IL-2 secreting CD4 + and CD8 + T cells (C and D, respectively) and TNF-a secreting CD4 + and CD8 + T cells (E and F, respectively) recognizing peptide subpools across the Gag, Pol and Env protein were measured by flow cytometry in all group 2 A, B and C participants (PGT121 and placebo recipients, N = 15) at baseline (pre-mAb) and at day 28 (post-mAb). For panels A-F, data are presented as median values + /− 95% CI; n = 4 (active) and n = 1 (placebo) for each subgroup. Frequencies of activated CD38 and Ki67 expressing IFN-γ secreting CD4 + and CD8 + T cells (G and H, respectively), and frequencies of PD-1 expressing IFN-γ secreting CD4 + and CD8 + T cells (I and J, respectively) at baseline (pre-mAb) and at day 28 (post-mAb) were assessed by flow cytometry. Boxplots display minimum, maximum, median and interquartile range; n = 4 (active) and n = 1 (placebo) for each subgroup.