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. 2021 Oct 12;27(10):1797–1805. doi: 10.1038/s41591-021-01497-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — Drug product memory phenotype composition as percentage of CD4+ or and CD8+ CAR T cells: naïve T cells (CD45RA+, CCR7+), central memory (CM) T cells (CD45RA-, CCR7+), effector memory (EM) T cells (CD45RA-, CCR7-), terminally differentiated T effector memory cells re-expressing CD45RA, TEMRA (CD45RA+, CCR7-). Drug product exhaustion phenotype composition based on percentage of CD4+ or CD8+ CAR T cells expressing TIM3, LAG3, PD-1 or TIGIT. Stacked bars show percentage of cells expressing single markers per individual patients.