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. 2021 Oct 12;27(10):1797–1805. doi: 10.1038/s41591-021-01497-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — a) Individual concentration-time profiles for AUTO3 transgene levels by qPCR in peripheral blood post AUTO3 infusion. b) Summary of CAR T cell kinetic parameters as measured in peripheral blood by qPCR. Cmax - maximum concentration; Tmax - Time to Cmax (Days), Tlast -Time to last measurable in blood (Days), AUC - area under the curve; AUC 0-28d - AUC from time zero to day 28; AUC 0-84d - AUC from time zero to day 84; Time to Cmax is the time to reach peak CAR T cell concentration. Dose Level 1, 0.3-2 ×10⁶ cells/kg, Dose Level 2, 3×10⁶ cells/kg, Dose level 3, 4.3-5 ×10⁶ cells/kg. Of Note: 1 non-responding patient did not have any CAR-T expansion and therefore was non-evaluable for kinetic parameter derivation.