TABLE 1.
Antigen | Sequence |
---|---|
VCA p18 | A V D T G S G G G G Q P H D T A P R G A R K K Q |
A V D T Q H D T A R G A R K K Q | |
MIXO (P,G) | G S G G G G P P |
G I E S N G E S G K S G K R R N |
Equimolar amounts of the appropriate subsets of amino acids (shown vertically for the mixotope) were introduced in each degenerate position during the synthesis. Theoretically, this produced sets of peptides containing 65,536 closely related combinatorial sequences.