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. 2021 Oct 4;78(5):1434–1449. doi: 10.1161/HYPERTENSIONAHA.121.17298

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© 2021 The Authors.

Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 1. — Acute eWAT stimulation with capsaicin (CAP) exacerbated mean arterial pressure (MAP) response in obese MSEW male mice. A, Blood pressure trace in mice fed a low fat diet (LF). B, Blood pressure trace in mice fed a high fat diet (HF) (C), 30-min area under the curve (AUC) in response to CAP. Data were analyzed by ANOVA repeated measures for continuous blood pressure trace and 2-way ANOVA followed by Tukey multiple comparisons post hoc test for AUC analysis. Data were reported as mean±SEM. n=8 per group. eWAT indicates epididymal white adipose tissue; MSEW, maternal separation and early weaning; and VEH, vehicle. *P<0.05 vs control.