Table 1.
Model input values for baseline patient characteristics of the VICTORIA ITT population
| Parameter | VICTORIA ITT population [n = 4731]a |
|---|---|
| Demographics | |
| Female | 1139 (24.1) |
| Age, years (mean) | 67.28 |
| Geographic region or race/ethnicity | |
| Eastern European | 1575 (33.3) |
| Western European | 781 (16.5) |
| Asia Pacific | 1152 (24.4) |
| Latin and South America | 704 (14.9) |
| North America, African American | 113 (2.4) |
| North America, Non-African American | 406 (8.6) |
| Laboratory results | |
| NT-proBNP, pg/mL (mean) | 4740.79 |
| eGFR, mL/min/1.73m2 (mean) | 61.50 |
| Predose sodium, mEq/L (mean) | 139.88 |
| Disease history | |
| Anemia | 997 (21.1) |
| COPD | 809 (17.1) |
| Diabetes mellitus | 2217 (46.9) |
| Ischemic etiology | 3035 (64.2) |
| WHFE | |
| HFH within 3–6 months before randomization | 806 (17.0) |
| HFH within 3 months before randomization | 3164 (66.9) |
| Intravenous diuretic for HF (without HFH) within 3 months before randomization | 761 (16.1) |
| Other | |
| LVEF, % (mean) | 28.93 |
| NYHA class | |
| I/II | 2794 (59.1) |
| III/IV | 1937 (40.9) |
| Heart rate, bpm (mean) | 73.13 |
| BMI, kg/m2 (mean) | 27.74 |
Data are expressed as n (%) unless otherwise specified
BMI body mass index, bpm beats per minute, COPD chronic obstructive pulmonary disease, eGFR estimated glomerular filtration rate, HF heart failure, HFH heart failure hospitalization, ITT intent-to-treat, LVEF left ventricular ejection fraction, mEq/L milliequivalents per liter, NT-proBNP N-terminal pro-B-type natriuretic peptide, NYHA New York Heart Association, WHFE worsening heart failure event
aThese were subjects with full information on the baseline patient characteristics selected for the multivariable parametric models for cardiovascular mortality and heart failure hospitalization. Subjects with missing values were not included