Table 1.
Immunohistochemical detection of YKL-40 protein expression in a multi-tumor tissue microarray Staining intensity was assessed on a scale from ‘0’ = negative over ‘1’ = weak to ‘4’ = high expression
| YKL-40 Staining Intensity % | Matrix Cells % | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Organ system | Tissue | Specific tumor entity | n | 0 | 1 | 2 | 3 | 4 | Pos | > Tumor |
| Skin | Basalioma | 41 | 4.9 | 36.6 | 46.3 | 12.2 | 0.0 | 76.2 | 48.8 | |
| Benign Naevus | 26 | 0.0 | 11.5 | 26.9 | 42.3 | 19.2 | 81.5 | 7.7 | ||
| Squamous cell carcinoma | 43 | 7.0 | 14.0 | 39.5 | 23.3 | 16.3 | 55.6 | 14.0 | ||
| Melanoma | 42 | 7.1 | 16.7 | 21.4 | 35.7 | 19.0 | 78.0 | 26.8 | ||
| Head, Chest, and Respiratory Tract | Larynx | Squamous cell carcinoma | 41 | 22.0 | 19.5 | 31.7 | 24.4 | 2.4 | 34.9 | 24.4 |
| Oral cavity | Squamous cell carcinoma | 50 | 2.0 | 10.0 | 32.0 | 48.0 | 8.0 | 71.4 | 10.2 | |
| Lung | Squamous cell carcinoma | 33 | 9.1 | 15.2 | 24.2 | 45.5 | 6.1 | 56.3 | 16.7 | |
| Bronchial carcinoma, large cell | 22 | 9.1 | 18.2 | 31.8 | 18.2 | 22.7 | 72.7 | 28.6 | ||
| Adenocarcinoma | 32 | 0.0 | 9.4 | 31.3 | 40.6 | 18.8 | 90.6 | 22.6 | ||
| Bronchoalveolar carcinoma | 6 | 0.0 | 33.3 | 50.0 | 16.7 | 0.0 | 16.7 | 0.0 | ||
| Small-cell carcinoma | 19 | 0.0 | 5.3 | 52.6 | 26.3 | 15.8 | 50.0 | 100.0 | ||
| Salivary glands | Parotis, pleomorphic adenoma | 48 | 58.3 | 20.8 | 18.8 | 2.1 | 0.0 | 2.1 | 60.4 | |
| Parotis, Warthin tumor | 44 | 2.3 | 22.7 | 25.0 | 43.2 | 6.8 | 0.0 | 2.3 | ||
| Basal cell adenoma | 14 | 7.1 | 28.6 | 35.7 | 28.6 | 0.0 | 21.4 | 7.1 | ||
| Gynecologic | Vagina | Squamous cell carcinoma | 24 | 29.2 | 20.8 | 25.0 | 16.7 | 8.3 | 45.8 | 37.5 |
| Vulva | Squamous cell carcinoma | 33 | 0.0 | 6.1 | 30.3 | 39.4 | 24.2 | 60.0 | 12.1 | |
| Cervix | Squamous cell carcinoma | 37 | 27.0 | 27.0 | 18.9 | 16.2 | 10.8 | 35.1 | 37.8 | |
| Adenocarcinoma | 44 | 2.3 | 11.4 | 40.9 | 34.1 | 11.4 | 55.6 | 6.8 | ||
| Endometrium | Carcinoma, endometroid | 47 | 55.3 | 27.7 | 17.0 | 0.0 | 0.0 | 4.3 | 59.6 | |
| Carcinoma, serous | 36 | 19.4 | 27.8 | 36.1 | 13.9 | 2.8 | 13.9 | 22.2 | ||
| Uterus | Stroma sarcoma | 12 | 8.3 | 8.3 | 50.0 | 33.3 | 0.0 | 50.0 | 16.7 | |
| Carcinosarcoma | 46 | 4.3 | 32.6 | 39.1 | 21.7 | 2.2 | 45.7 | 13.0 | ||
| Ovaries | Carcinoma, endometroid | 25 | 4.0 | 28.0 | 20.0 | 32.0 | 16.0 | 67.9 | 16.0 | |
| Carcinoma, serous | 39 | 5.1 | 15.4 | 46.2 | 23.1 | 10.3 | 76.2 | 26.3 | ||
| Carcinoma, mucinous | 23 | 43.5 | 17.4 | 26.1 | 8.7 | 4.3 | 50.0 | 56.5 | ||
| Brenner tumor | 5 | 80.0 | 0.0 | 20.0 | 0.0 | 0.0 | 66.7 | 80.0 | ||
| Breast | Carcinoma, ductal (NST) | 30 | 56.7 | 20.0 | 13.3 | 10.0 | 0.0 | 10.0 | 56.7 | |
| Carcinoma, lobular | 28 | 7.1 | 25.0 | 46.4 | 21.4 | 0.0 | 63.3 | 25.9 | ||
| Carcinoma, medullary | 11 | 0.0 | 0.0 | 63.6 | 36.4 | 0.0 | 45.5 | 0.0 | ||
| Carcinoma, tubular | 10 | 0.0 | 20.0 | 20.0 | 40.0 | 20.0 | 83.3 | 20.0 | ||
| Carcinoma, mucinous | 14 | 7.1 | 21.4 | 14.3 | 28.6 | 28.6 | 35.7 | 21.4 | ||
| Carcinoma, phyllodes | 44 | 18.2 | 43.2 | 27.3 | 11.4 | 0.0 | 47.8 | 50.0 | ||
| Gastrointestinal | Large intestine | Adenoma, low grade | 17 | 29.4 | 23.5 | 29.4 | 11.8 | 5.9 | 17.6 | 29.4 |
| Adenoma, high grade | 19 | 21.1 | 21.1 | 26.3 | 21.1 | 10.5 | 55.0 | 31.6 | ||
| Adenocarcinoma | 32 | 3.1 | 15.6 | 34.4 | 43.8 | 3.1 | 56.3 | 12.5 | ||
| Small intestine | Adenocarcinoma | 6 | 0.0 | 0.0 | 83.3 | 16.7 | 0.0 | 71.4 | 33.3 | |
| Stomach | Carcinoma, diffuse type | 29 | 65.5 | 27.6 | 6.9 | 0.0 | 0.0 | 37.5 | 86.2 | |
| Carcinoma, intestinal type | 30 | 3.3 | 16.7 | 46.7 | 26.7 | 6.7 | 74.2 | 20.7 | ||
| Esophagus | Adenocarcinoma | 31 | 29.0 | 32.3 | 22.6 | 12.9 | 3.2 | 34.4 | 35.5 | |
| Squamous cell carcinoma | 26 | 7.7 | 15.4 | 30.8 | 26.9 | 19.2 | 59.3 | 23.1 | ||
| Anal canal | Squamous cell carcinoma | 18 | 27.8 | 11.1 | 33.3 | 27.8 | 0.0 | 42.1 | 27.8 | |
| Liver | Cholangiocellular carcinoma | 27 | 11.1 | 22.2 | 18.5 | 18.5 | 29.6 | 71.4 | 22.2 | |
| Hepatocellular carcinoma | 39 | 2.6 | 7.7 | 38.5 | 41.0 | 10.3 | 39.4 | 6.1 | ||
| Pancreas | Adenocarcinoma, ductal | 36 | 36.1 | 33.3 | 25.0 | 5.6 | 0.0 | 25.6 | 50.0 | |
| Adenocarcinoma, papillary | 18 | 33.3 | 50.0 | 11.1 | 5.6 | 0.0 | 16.7 | 44.4 | ||
| Neuroendocrine Tumor | 27 | 7.4 | 18.5 | 40.7 | 18.5 | 14.8 | 57.1 | 14.8 | ||
| Gastrointestinal Stroma tumor | 33 | 6.1 | 12.1 | 42.4 | 36.4 | 3.0 | 73.0 | 25.0 | ||
| Urogenital | Urothelial | Carcinoma, pTa | 35 | 0.0 | 8.6 | 20.0 | 42.9 | 28.6 | 80.6 | 3.4 |
| Carcinoma, pT2-4 | 43 | 0.0 | 9.3 | 25.6 | 44.2 | 20.9 | 97.6 | 23.8 | ||
| Kidney | Carcinoma, clear cell | 44 | 4.5 | 18.2 | 43.2 | 31.8 | 2.3 | 54.5 | 11.6 | |
| Carcinoma, papillary | 34 | 0.0 | 38.2 | 29.4 | 29.4 | 2.9 | 47.2 | 12.1 | ||
| Carcinoma, chromophobe | 43 | 18.6 | 16.3 | 23.3 | 32.6 | 9.3 | 16.3 | 20.9 | ||
| Oncocytoma | 41 | 2.4 | 0.0 | 9.8 | 19.5 | 68.3 | 56.1 | 2.4 | ||
| Prostate | Adenocarcinoma | 46 | 32.6 | 17.4 | 30.4 | 10.9 | 8.7 | 60.9 | 52.2 | |
| Germ cell tumor | Seminoma | 48 | 2.1 | 16.7 | 68.8 | 12.5 | 0.0 | 68.1 | 23.4 | |
| Carcinoma, embryonal | 43 | 4.7 | 18.6 | 58.1 | 18.6 | 0.0 | 55.3 | 26.3 | ||
| Yolk sac tumor | 41 | 4.9 | 19.5 | 41.5 | 22.0 | 12.2 | 57.9 | 18.9 | ||
| Teratoma | 29 | 3.4 | 10.3 | 41.4 | 27.6 | 17.2 | 77.4 | 39.3 | ||
| Endocrine | Thyroid | Adenoma | 42 | 11.9 | 40.5 | 31.0 | 11.9 | 4.8 | 45.2 | 23.8 |
| Papillary carcinoma | 45 | 37.8 | 20.0 | 22.2 | 17.8 | 2.2 | 28.3 | 37.8 | ||
| Follicular carcinoma | 45 | 4.4 | 26.7 | 42.2 | 17.8 | 8.9 | 47.8 | 11.1 | ||
| Medullary carcinoma | 45 | 40.0 | 17.8 | 35.6 | 6.7 | 0.0 | 28.3 | 46.7 | ||
| Anaplastic carcinoma | 24 | 8.3 | 20.8 | 33.3 | 25.0 | 12.5 | 37.5 | 20.8 | ||
| Adrenal gland | Adenoma | 43 | 2.3 | 9.3 | 62.8 | 25.6 | 0.0 | 7.0 | 4.7 | |
| Carcinoma | 13 | 7.7 | 23.1 | 30.8 | 23.1 | 15.4 | 15.4 | 8.3 | ||
| Pheochromocytoma | 26 | 19.2 | 23.1 | 42.3 | 15.4 | 0.0 | 20.0 | 20.8 | ||
| Neuroendocrine tumor | 22 | 18.2 | 18.2 | 54.5 | 4.5 | 4.5 | 45.8 | 36.4 | ||
| Hematologic | Hodgkin-Lymphoma | 37 | 62.2 | 24.3 | 10.8 | 2.7 | 0.0 | 45.9 | 75.7 | |
| Non-Hodgkin-Lymphoma | 42 | 54.8 | 26.2 | 14.3 | 4.8 | 0.0 | 47.6 | 57.1 | ||
| Thymoma | 26 | 7.7 | 53.8 | 34.6 | 3.8 | 0.0 | 30.8 | 30.8 | ||
| Soft tissue | Leiomyoma | 48 | 8,3 | 29.2 | 45.8 | 14.6 | 2.1 | 0.0 | 8.3 | |
| Leiomyosarcoma | 48 | 8,3 | 10.4 | 56.3 | 22.9 | 2.1 | 35.4 | 12.5 | ||