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. 2021 Sep 12;44(5):1119–1131. doi: 10.1007/s13402-021-00622-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — FXR/SNAI2/miR-1 signaling pathway promotes BA-induced gastric IM. Under the stimulation of bile acids, enhanced FXR gene expression increases the expression of SNAI2, which in turn decreases the inhibitory effect of miR-1 on HDAC6 and HNF4α expression. Upregulated HDAC6 and HNF4α interact with each other, which further promotes upregulation of CDX2, KLF4 and MUC2, thereby promoting gastric IM development