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. 2021 Oct 15;37(6):109920. doi: 10.1016/j.celrep.2021.109920

Figure 5.

Figure 5

Metabolic profiling identifies a key role for glycolysis in SARS-CoV-2 infection

(A and B) Hierarchical clustering analysis (A) and heatmap (B) of metabolic profiles for mock- or SARS-CoV-2 (MOI = 0.2)-infected hPSC-AOs at 48 hpi. n = 4 biological replicates for mock and N = 3 biological replicates for SARS-CoV-2.

(C and D) Hierarchical clustering analysis (C) and heatmap (D) of metabolic profiles for control- or 10 μM GW6471-treated hPSC-AOs at 48 hpi (MOI = 0.2). n = 3 biological replicates.

(E) Heatmap of genes encoding enzymes involved in the glycolytic pathway of control- or 10 μM GW6471-treated hPSC-AOs at 48 hpi (MOI = 0.2). n = 3 biological replicates.