Table 3. Comparisons of major grading standards for liver inflammation.

Score	Knodell’s scoring system			Score	Scheuer’s scoring system
	Periportal inflammation with or without bridging necrosis	Intralobular degeneration and focal necrosis	Portal inflammation		Portal/periportal activity	Intralobular activity
0	None	None	None	0	None or minimal	None
1	Mild piecemeal necrosis	Mild (acidophilic bodies, ballooning degeneration or scattered foci, or both of hepatocellular necrosis in <⅓ of lobules or nodules)	Mild (a few inflammatory cells in <⅓ of portal tracts)	1	Portal inflammation alone	Inflammation but no necrosis
3	Moderate piecemeal necrosis (involving <50% of the circumference of most portal tracts)	Moderate (involving ⅓–⅓ of lobules or nodules)	Moderate (increased inflammatory cells in ⅓–⅔ of portal tracts)	2	Mild piecemeal necrosis	Focal necrosis or acidophilic bodies
4	Marked piecemeal necrosis (involving >50% of the circumference of most portal tracts)	Marked (involving >⅔ of lobules or nodules)	Marked (dense inflammatory cells in >⅔ of portal tracts)	3	Moderate piecemeal necrosis	Marked focal cell damage
5	Moderate piecemeal necrosis plus bridging necrosis	–	–	4	Marked piecemeal necrosis	Damage includes bridging necrosis
6	Marked piecemeal necrosis plus bridging necrosis	–	–
10	Multilobular necrosis	–	–

Score	Wang Tailing’s scoring system		Score	Ishak’s scoring system
	Portal/periportal area	Intralobular area		Portal inflammation	Periportal or periseptal interface inflammation	Focal necrosis, apoptosis, or focal inflammation	Confluent necrosis
0	No inflammation	No inflammation	0	None	None	None	None
1	Portal inflammation	Degeneration and a few necrotic foci	1	Mild, involving some or all portal areas	Mild (focal, involving few portal areas)	≤1 foci per 10× objective	Focal confluent necrosis
2	Mild piecemeal necrosis	Degeneration, spotted or focal necrosis or acidophilic bodies	2	Marked, involving some or all portal areas	Mild/moderate (focal, involving most portal areas)	2–4 foci per 10× objective	Zone 3 necrosis in some areas
3	Moderate piecemeal necrosis	Degeneration, severe necrosis, or bridging necrosis	3	Moderate to severe, involving all portal areas	Moderate (continuous around <50% of tracts or septa)	5–10 foci per 10× objective	Zone 3 necrosis in most areas
4	Marked piecemeal necrosis	Bridging necrosis involving multiple lobules	4	Severe, involving all portal areas	Severe (continuous around >50% of tracts or septa)	>10 foci per 10× objective	Zone 3 necrosis and occasional portal-central bridging necrosis
			5	–	–	–	Zone 3 necrosis and multiple portal-central bridging necrosis
			6	–	–	–	Panacinar or multiacinar necrosis

–, not applicable.