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. 2021 Oct 14;11:20407. doi: 10.1038/s41598-021-99538-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Electrophysiological characterization of cortical neuron cultures on MEAs. (a) Photograph of a 60 electrode MEA device used in the study. (b) Phase-contrast image of cortical neurons in culture at DIV 14. The distance between electrodes is 200 µm. Each black dot corresponds to one of the recording electrodes. (c) Sample traces of spontaneous electrical activity recorded by three channels. Electrical events, spikes and bursts, that crossed a threshold (horizontal black line) were recorded. (d) Spontaneous activity of cortical neurons was analyzed according to electrophysiological features of spikes, bursts, synchrony, and connectivity. The figure was created using MC_Rack 4.6 (https://www.multichannelsystems.com/software/mc-rack) (c) and Microsoft PowerPoint 365 (https://www.microsoft.com/powerpoint) (d).