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. 2021 Oct 14;7:94. doi: 10.1038/s41531-021-00239-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Box plot of top six biomarker iPD vs CN and AD (median values in picomoles/µl serum, data taken from Table 1). *** indicates a p value of <0.001 and ***** of <0.00001. B Multivariate ROC analyses resulted in a linear model being able to separate iPD from CN and AD from CN. In the case of iPD vs CN, a panel of seven metabolites resulted in an AUC value of 0.905. For further details, see Table 2C.