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. 2021 Oct 14;7:293. doi: 10.1038/s41420-021-00675-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Optical microscope images of liver tumor organoids after treating with the mETC complex I inhibitors (Rotenone, ROT; Metformin, Met) and complex III inhibitors (Antimycin A, AMA; Myxothiazol, MYXO) for 48 h (N = 3). B Optical microscope images of liver tumor organoids and normal liver organoids after treating with AMA, Met, and ROT for 48 h (N = 9). C The growth rates of tumor and normal liver organoids were measured by Alamar Blue assays (N = 9). Results are presented as mean ± SD, and group differences were tested by Mann–Whitney U test.