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. 2021 Oct 14;11:20438. doi: 10.1038/s41598-021-99736-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of DLEU1 depletion on histone modification in OSCC cells. (a) Workflow of the current study. HSC3 cells were transfected with an siRNA targeting DLEU1 (siDLEU1-2) or a control siRNA, after which microarray and ChIP-seq analyses were performed. (b) Metagene plots of H3K4me3 (left) and H3K27ac (right) around the transcription start site (TSS) regions of RefSeq genes in HSC3 cells transfected with the indicated siRNA. (c) Heatmaps showing levels of H3K4me3 and H3K27ac around the TSS regions of 300 selected genes. (d) Results of Gene Ontology (GO) and pathway analyses of the 300 selected genes. (e) ChIP-seq results of representative genes in HSC3 cells transfected with the indicated siRNAs. Gene structures are shown at the top. Red arrows indicate locations analyzed by ChIP-qPCR. (f) Results of ChIP-qPCR analysis showing levels of H3K27ac at TSS regions of the indicated genes in HSC3 cells transfected with the indicated siRNA. *P < 0.05.