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. 2021 Oct 14;11:20438. doi: 10.1038/s41598-021-99736-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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DLEU1 upregulates interferon receptor genes and activates JAK-STAT signaling in OSCC cells. (a) qRT-PCR analysis of IFNAR1 (left) and IFNGR2 (right) in OSCC cell lines transfected with the indicated siRNAs. (b) qRT-PCR analysis of IFNAR1 (left) and IFNGR2 (right) in OSCC cell lines transfected with the indicated vectors. (c, d) Western blot analysis of total and phosphorylated STAT1 in the indicated OSCC cells with DLEU1 knockdown (c) or ectopic DLEU1 expression (d). (e) Results of ISRE reporter assays in OSCC cells transfected with the indicated vectors. **P < 0.01.