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. 2021 Oct 14;12(10):945. doi: 10.1038/s41419-021-04208-3

Fig. 5. TRIM31 exerts the tumor-suppressive function via p53.

Fig. 5

a The MCF7 cells stably interfere with TRIM31 were transfected with Flag-p53 plasmid, and the expression of TRIM31 and p53 were detected by western blot. b The cell survival of MCF7 at 72 h was detected by CCK8 assay. c The colony formation assay was performed to detect the cell proliferation of MCF7 cells. d The transwell migration assay was performed to detect the migration capability of MCF7 cells. e The ZR-75-30 cells stably overexpress TRIM31 were transfected with p53 special shRNA, and the TRIM31 and p53 expression were detected by western blot. f The CCK8 analyzed the cell survival of ZR-75-30 at 72 h. g The colony formation was performed to detect the cell proliferation of ZR-75-30 cells. h The transwell migration assay was performed to detect the migration capability of ZR-75-30, Bar length: 100 μm. Data are shown as the mean ± SD of at least three independent experiments, and the significant level was identified by *P < 0.05, **P < 0.01 and ***P < 0.001.