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. 2021 Oct 14;12:6013. doi: 10.1038/s41467-021-26293-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Comparison between myogenic progression of SCs expressing physiological or reduced NF-YA levels (blue lines = NF-YA^WT; red lines = NF-YA^cKO). Quiescent SCs that survive to NF-YA loss (NF-YA^cKO) are quickly activated and committed to early differentiation; nevertheless, they cannot accomplish terminal differentiation. This finally affects muscle regeneration following injury in NF-YA^cKO mice. The predominant phases and related markers involved in early and late stages of SCs differentiation are indicated. Created with BioRender.com.