Table 3.
Logistic analysis for RA patients with severe sarcopenia.
| Variables | Univariate | Multivariate | ||||||
|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | ||||||
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |
| Age (1 year) | 1.15 (1.08–1.22) | < 0.0001 | 1.17 (1.09–1.25) | < 0.0001 | 1.21 (1.10–1.33) | < 0.0001 | 1.21 (1.10–1.33) | < 0.0001 |
| Body mass index (1 kg/m2) | 0.76 (0.67–0.86) | < 0.0001 | 0.72 (0.62–0.84) | < 0.0001 | 0.76 (0.60–0.95) | 0.0085 | 0.76 (0.60–0.95) | 0.010 |
| Low 25(OH)D status (≦16.0 ng/ml) | 4.25 (1.99–9.09) | < 0.0001 | 4.42 (1.80–10.8) | 0.0007 | 5.92 (1.98–17.7) | 0.0006 | 6.00 (1.99–18.08) | 0.0006 |
| DAS28-ESR | 1.58 (1.09–2.31) | 0.015 | 1.03 (0.62–1.74) | 0.90 | 1.23 (0.86–1.76) | 0.88 | ||
| Stage (3, 4 vs. 1, 2) | 4.44 (1.74–11.4) | 0.0005 | 4.33 (1.33–14.08) | 0.0010 | 4.40 (1.35–14.32) | 0.0097 | ||
| HAQ | 4.03 (2.19–7.41) | < 0.0001 | ||||||
| Methotrexate use | 0.58 (0.28–1.19) | 0.14 | 2.18 (0.66–7.22) | 0.19 | 2.18 (0.66–7.22) | 0.19 | ||
| Prednisolone use | 2.91 (1.39–6.11) | 0.0049 | 2.45 (0.74–8.06) | 0.09 | 2.45 (0.74–8.06) | 0.13 | ||
| Biological agents use | 0.47 (0.21–1.03) | 0.058 | 0.70 (0.22–2.21) | 0.52 | 0.70 (0.22–2.21) | 0.54 | ||
| MNA-SF | 0.70 (0.59–0.85) | < 0.0001 | 0.91 (0.66–1.24) | 0.54 | 0.90 (0.66–1.24) | 0.53 | ||
| Osteoporosis medication (+) | 1.72 (0.82–3.59) | 0.15 | 1.22 (0.40–3.72) | 0.73 | ||||
Results of univariate (left) and multivariate (right) logistic analyses for independent variables associated with severe sarcopenia. Model 1 was adjusted for vitamin D status, age, and body mass index. Model 2 was adjusted for variables in model 1 plus nutrition status (MNA-SF), and RA-related factors (DAS28-ESR, Stage, HAQ, and therapeutics (use of prednisolone, biologics, and methotrexate)). Model 3 was adjusted for variables in model 2 plus the prevalence of osteoporosis medication.
RA rheumatoid arthritis, DAS28 disease activity score using 28 joints, HAQ health assessment questionnaire, MNA-SF Mini Nutritional Assessment Short-Form.