Table 1.
The severity of adverse drug reactions was different in patients with different characteristic.
| Variables | Total N (%) | Nonserious N (%) | Serious N (%) | P value | Effect size (φ) |
|---|---|---|---|---|---|
| Total | 394,037 (100) | 358,295 (90.90) | 35,742 (9.10) | ||
| Age (years) | |||||
| 0–6 | 22,579 (5.73) | 20,888 (92.51) | 1691 (7.49) | < 0.001 | 0.560 |
| 6–18 | 15,970 (4.05) | 14,718 (92.16) | 1252 (7.84) | ||
| 18–35 | 56,365 (14.30) | 52,659 (93.42) | 3706 (6.58) | ||
| 35–60 | 156,059 (39.61) | 142,930 (91.59) | 13,129 (8.41) | ||
| 60–80 | 124,068 (31.48) | 110,619 (89.16) | 13,449 (10.84) | ||
| > 80 | 18,640 (4.73) | 16,468 (88.35) | 2172 (11.65) | ||
| Missing | 356 (0.10) | ||||
| Gender | |||||
| Male | 187,473 (47.58) | 170,404 (90.90) | 17,069 (9.10) | 0.496 | -0.001 |
| Female | 206,042 (52.29) | 187,411 (90.96) | 18,631 (9.04) | ||
| Missing | 522 (0.13) | ||||
| Hospital level | |||||
| Unrated | 31,497 (7.99) | 30,416 (96.57) | 1081 (3.43) | < 0.001 | 0.119 |
| 1 | 139,307 (35.35) | 130,172 (93.44) | 9135 (6.56) | ||
| 2 | 138,480 (35.14) | 125,431 (90.58) | 13,049 (9.42) | ||
| 3 | 84,753 (21.50) | 72,276 (85.28) | 12,477 (14.72) | ||
| Medication method | |||||
| Oral | 165,060 (41.89) | 159,655 (96.72) | 5405 (3.27) | < 0.001 | 0.180 |
| Injection | 218,327 (55.41) | 188,392 (86.29) | 29,935 (13.71) | ||
| Others | 10,650 (2.70) | 10,248 (96.23) | 402 (3.77) | ||
| Type of drug | |||||
| Chemical compound | 302,078 (76.66) | 273,904 (90.67) | 28,174 (9.33) | < 0.001 | 0.410 |
| Chinese patent medicine | 72,218 (18.33) | 66,777 (92.47) | 5441 (7.53) | ||
| Imported and biologics | 12,163 (3.09) | 10,415 (85.63) | 1748 (14.37) | ||
| Past history | |||||
| No | 257,061 (65.24) | 233,255 (90.74) | 23,806 (9.26) | < 0.001 | 0.570 |
| Yes | 5922 (1.50) | 4648 (78.49) | 1274 (21.51) | ||
| Unknown | 131,054 (33.26) | 120,392 (91.86) | 10,662 (8.14) | ||
| ADRs occurrence | |||||
| First | 387,642 (98.38) | 352,672 (90.98) | 34,970 (9.02) | < 0.001 | 0.013 |
| Again | 6395 (1.62) | 5623 (87.93) | 772 (12.07) | ||
| New ADRs | |||||
| Yes | 101,727 (25.82) | 91,208 (89.66) | 10,519 (10.34) | < 0.001 | 0.026 |
| No | 292,310 (74.18) | 267,087 (91.37) | 25,223 (8.63) | ||