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. 2021 Oct 14;11:20402. doi: 10.1038/s41598-021-99908-3

Table 3.

SADRs in primary and non-primary medical institutions.

Primary health institutions Yes
OR (95% CI)
No
OR (95% CI)
Gender (refer to male)
Female 0.956 (0.91–1.003) 1.034* (1.004–1.064)
Age (refer to 18–35)
0–6 0.848* (0.742–0.969) 0.950 (0.884–1.022)
6–18 0.912 (0.805–1.034) 1.208** (1.109–1.317)
35–60 1.082* (1.005–1.166) 1.324** (1.262–1.389)
60–80 1.145** (1.062–1.234) 1.496** (1.427–1.570)
> 80 1.225** (1.078–1.392) 1.341** (1.253–1.435)
Number of diseases (refer to 1)
≥ 2 1.394** (1.274–1.525) 1.207** (1.166–1.250)
Polypharmacy (refer to no)
yes 2.708** (1.613–4.548) 3.332** (2.963–3.747)
Type of drug (refer to chemical compound)
Chinese patent medicine 1.079** (1.022–1.139) 0.936** (0.899–0.975)
Imported and biological product 1.173 (0.990–1.390) 1.392** (1.311–1.478)
Past history (refer to no)
Yes 1.625** (1.222–2.161) 1.884** (1.754–2.025)
Unknown 0.789** (0.753–0.827) 1.043** (1.011–1.075)
Past behavior (refer to no)
Smoking and drinking 1.333** (1.242–1.430) 1.198** (1.136–1.263)
Allergy 0.875 (0.643–1.190) 1.080 (0.982–1.189)
History of illness and surgery 0.964 (0.752–1.234) 1.304** (1.197–1.420)
Medication (refer to oral)
Injection 7.353** (6.947–7.783) 3.335** (3.205–3.469)
Others 1.016 (0.742–1.392) 1.054 (0.936–1.188)
Time from medication to ADR (refer to < 3)
≥ 3 1.368** (1.221–1.533) 2.312** (2.241–2.385)
Season (refer to spring)
Summer 1.185** (1.109–1.265) 1.033 (0.993–1.074)
Autumn 1.387** (1.304–1.476) 1.193** (1.150–1.238)
Winter 1.560** (1.439–1.691) 1.135** (1.085–1.186)
ADRs occurrence (refer to first)
Again 0.768 (0.569–1.037) 0.870** (0.792–0.956)
New adverse reactions (refer to no)
Yes 1.597** (1.524–1.673) 1.385** (1.342–1.429)