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. 2021 Oct 15;6:355. doi: 10.1038/s41392-021-00751-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Integrated analysis of whole exome and transcriptome sequencing. a Sample correlation heat map based on expression matrix; different colors represent different correlation coefficients. b Volcano plot of eight upregulated and five downregulated differentially expressed genes between PR and non-PR group, each of them labeled the names of the first five genes. c Immune analysis of PR versus non-PR group from our cohort (Wilcoxon signed-rank test). d M1/M2 macrophage ratio of PR versus non-PR from our cohort (Wilcoxon signed-rank test). e M1/M2 macrophage ratio of DSPP-mutant versus wild-type tumors from EGFR-mutant samples obtained from TCGA (Wilcoxon signed-rank test). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001