Figure 5.

Longitudinal assessment of liver OTC activity

(A) Increase of OTC activity after AAVLK03.hOTC injection over physiological OTC activity. (B) VGCN over time. Increase of OTC activity after AAVLK03.hOTC injection over physiological expression according to gender in (C) low- and (D) high-dose groups. The physiological OTC activity is the average of 3 control non-human primates from the same gender. Horizontal lines display the mean ± SEM. (B) Unpaired two-tailed Student’s t test, ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.