Table 2.

Classification Criteria for Birdshot Chorioretinitis

Criteria ([#’s 1, 2, and 3] OR # 4)

1. Characteristic bilateral multifocal choroiditis on ophthalmoscopy

a. Multifocal cream-colored or yellow-orange, oval or round choroidal lesions (“birdshot spots”)

AND

2. Absent to mild anterior chamber inflammation

a. Absent to mild anterior chamber cells AND

b. No keratic precipitates AND

c. No posterior synechiae

AND

3. Absent to moderate vitritis

OR

4. Multifocal choroiditis with

a. Positive HLA-A29 test AND either (b. or c.)

b. Characteristic “birdshot” spots (multifocal cream-colored or yellow-orange, oval or round choroidal lesions) on ophthalmoscopy OR

c. Characteristic indocyanine green angiogram (multifocal hypofluorescent spots) without characteristic “birdshot” spots on ophthalmoscopy

Exclusions

1. Positive serologic test for syphilis using a treponemal test

2. Evidence of sarcoidosis (either bilateral hilar adenopathy on chest imaging or tissue biopsy demonstrating non-caseating granulomata)*

3. Evidence of intraocular lymphoma on diagnostic vitrectomy or tissue biopsy

^*Possible sarcoidosis should be evaluated with chest imaging at a minimum.