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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Alzheimers Dement. 2021 Apr 15;17(10):1756–1762. doi: 10.1002/alz.12324

Figure 2.

Figure 2.

Trajectories of cognitive performance and IADL difficulties by baseline NFL and cognitive group

Model-predicted values of memory performance and Alzheimer’s preclinical composite score (mPACC) by cognitive group. Graphs illustrate predicted memory performance among those with (a) low baseline NFL and (b) high baseline NFL and Alzheimer’s preclinical composite score among those with (c) low baseline NFL and (d) high baseline NFL adjusted for age, education, sex, APOE ε4 allele frequency, and p-tau/Aβ positivity. Low and high NFL were determined by a median split of the values in the analytic sample. Shaded area represents 95% confidence intervals. NFL=neurofilament light; CN=cognitively normal; Obj-SCD=objectively-defined subtle cognitive difficulties; MCI=mild cognitive impairment.