Table 3.
Measures of functional status, assessment time points, and analytic approach by study type.
| Characteristic | Overall No. (%) (N=44) | Older adult-specific studies No. (%) (n=17) | Non-older adult-specific studies No. (%) (n=27) | p-valuea |
|---|---|---|---|---|
| Measures of functional status | ||||
| Patient-reported outcomeb | 43 (98) | 17 (100) | 26 (96) | 1.00 |
| EORTC QLQ-C30 | 15 (34) | 5 (11) | 10 (37) | |
| ADL | 9 (20) | 7 (16) | 2 (7) | |
| IADL | 7 (16) | 5 (11) | 2 (7) | |
| Physical performance testb | 9 (20) | 3 (18) | 6 (22) | 1.00 |
| Grip strength | 8 (18) | 3 (18) | 5 (19) | |
| Walking test | 6 (14) | 3 (19) | 3 (11) | |
| Chair stands | 5 (11) | 1 (12) | 4 (15) | |
| Clinician-reported | 4 (9) | 1 (6) | 3 (11) | 1.00 |
| ECOG PS | 3 (7) | 1 (6) | 2 (7) | |
| KPS | 1 (2) | 0 (0) | 1 (4) | |
| Assessment time points | ||||
| Pretreatment and 1 follow-up | 9 (20) | 3 (18) | 6 (22) | 0.91 |
| Pretreatment and 2 follow-ups | 6 (14) | 3 (18) | 3 (11) | |
| Pretreatment and ≥3 follow-ups | 22 (50) | 8 (47) | 14 (52) | |
| Other assessment schedulec | 7 (16) | 3 (18) | 4 (15) | |
| Analytic approach | ||||
| Change score between two assessments | 21 (48) | 6 (35) | 15 (56) | 0.008 |
| Longitudinal analysis | 14 (32) | 3 (18) | 11 (41) | |
| Dichotomous functional decline | 6 (14) | 5 (29) | 1 (4) | |
| Time to deterioration | 2 (5) | 2 (12) | 0 (0) | |
| Other analysisd | 1 (2) | 1 (6) | 0 (0) |
Abbreviations: ADL, activities of daily living; ECOG PS, Eastern Cooperative Oncology Group performance status; EORTC QLQ-C30, European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-C30; IADL, instrumental activities of daily living; KPS, Karnofsky Performance Status.
a
Fisher’s exact test comparing older adult-specific studies and non-older adult-specific studies.
b
Only the three most common measures of functional status within each subgroup are shown.
c
Other assessment schedule: Initial assessment occurred after initiation of systemic therapy.
d
Other analysis: Association with patient-reported change in physical condition.