Table 3.
Novel antibodies associated with paraneoplastic neuropathy.
| Antibody (antigen) | Localization (intracellular/surface) | Types of neuropathy | Associated tumors |
|---|---|---|---|
| AGNA/SOX1 | Intracellular | Sensory neuronopathy, sensorimotor neuropathy | SCLC |
| ITPR1 | Intracellular | Sensorimotor polyneuropathy | Lung, Multiple Myeloma |
| KLHL 11 | Intracellular | Myeloneuropathy | Testicular seminoma |
| LZUP4 (Leucin-Zipper 4) | Intracellular | Motor neuropathy, polyradiculopathy | Germ cell tumors |
| NfL (Neurofilament light chain) | Intracellular | Peripheral and cranial neuropathy | Neuroendocrine lineage neoplasms |
| CASPR2 | Surface | Neuromyotonia, painful neuropathy, Morvan syndrome | Thymoma (20–30%) |
| LGI1 | Surface | Neuromyotonia, painful neuropathy | Thymoma (5–10%) |
| Netrin 1 receptors | Surface | Neuromyotonia | Thymoma |
| Morvan syndrome |