Table 1.

I3C and DIM inhibition of human T-ALL cell growth in vitro and in vivo.

Indole	Proliferationa IC50 (μM)	Viabilitya IC50 (μM)	Tumor Volume Reduction (%)b	Tumor Doubling Time Increase (%)
I3C	122	223	24 (500 ppm) 27 (2,000 ppm)	18 (500 ppm) 31 (2,000 ppm)c
DIM	15	27	44 (100 ppm)c	59 (100 ppm)d
Ratio I3C/DIM	8.1	8.3	–	–

^aFollowing a 48 h incubation.

^bVolume determined at conclusion (28 days post engraftment).

^cp < 0.01.

^dp < 0.001.