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. 2021 Oct 1;9:694003. doi: 10.3389/fcell.2021.694003

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Copyright © 2021 Xiao, Liu, Yuan, Chen and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prognosis and biological characteristics of each ferroptosis-related subtype. (A) Consensus clustering matrix for k = 2. (B) Principal component analysis for the transcriptome profiles of three ferroptosis-related subtypes. (C) Kaplan–Meier analysis of patients in the three different ferroptosis-related subtypes. (D) Expression profiles of 32 ferroptosis-related genes in three subtypes. ns, no significance. ***p < 0.001; ****p < 0.0001, as determined by the Kruskal–Wallis test. (E,F) Enrichment degree of biological pathways in the different ferroptosis-related subtypes shown in a heatmap: cluster 1 vs. cluster 2 (E) and cluster 2 vs. cluster 3 (F).