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. 2021 Oct 1;9:694003. doi: 10.3389/fcell.2021.694003

FIGURE 3.

FIGURE 3

Association between consensus gastric cancer molecular subtypes and the ferroptosis-related clusters. (A) Expression profiles of the 32 ferroptosis-related genes in the Asian Cancer Research Group (ACRG) cohort. The ferroptosis-related clusters, ACRG molecular subtypes, histology subtype, tumor stage, survival status, relapse status, gender, and age were used as patient annotations. (B) Relative frequency of the ACRG molecular subtypes in the three clusters. (C) Relative frequency of Lauren’s histological subtypes in three clusters. (D) Biological characteristics of each ACRG molecular subtype shown in heatmaps. (E) Different activation status of the gene signatures characterized by distinct ACRG molecular subtypes in ferroptosis clusters. ****p < 0.0001). ns, no significance. (F) Different enrichment status of numerous metabolism pathways in the Kyoto Encyclopedia of Genes and Genomes (KEGG) database in three distinct ferroptosis clusters (****p < 0.0001). ns, no significance.