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. 2021 Oct 1;9:694003. doi: 10.3389/fcell.2021.694003

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Copyright © 2021 Xiao, Liu, Yuan, Chen and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical features and transcriptome characteristics of distinct gene clusters. (A) Unsupervised clustering for the 933 overlapping ferroptosis-related genes classified patients in the Asian Cancer Research Group (ACRG) cohort into three gene clusters with distinct biological characteristics. The gene clusters, ferroptosis-related clusters, ACRG molecular subtypes, histology subtype, tumor stage, survival status, relapse status, gender, and age were used as patient annotations. (B) Gene Ontology (GO) biological pathway enrichment analysis for the 933 overlapping phenotype-related genes. (C) Kaplan–Meier analysis of patients in three different ferroptosis-related gene clusters in the ACRG cohort. (D) Relapse-free survival analysis of the patients in three different ferroptosis-related gene clusters in the ACRG cohort.