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. 2021 Oct 1;9:694003. doi: 10.3389/fcell.2021.694003

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Copyright © 2021 Xiao, Liu, Yuan, Chen and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Predictive value of the ferroptosis score for response to immunotherapy. (A) Different expression profiles of immune checkpoint-related genes in patients with low or high ferroptosis scores in the Asian Cancer Research Group (ACRG) cohort (**p < 0.01; ***p < 0.001; ****p < 0.0001). ns, no significance. (B) Different activation status of immunotherapy-positive gene signatures in patients with low or high ferroptosis scores in the ACRG cohort (***p < 0.001; ****p < 0.0001). ns, no significance. (C) Kaplan–Meier curves showing overall survival in patients with low or high ferroptosis scores in the immunotherapy cohort. (D) Distribution of the ferroptosis scores in distinct anti-PD-L1 clinical response groups. (E) Relative frequency of each anti-PD-L1 clinical response group in groups with low or high ferroptosis scores.