TABLE 1.

Incidental findings in CPIC guidelines.

Gene (medication)	Incidental finding
CYP2D6 (SSRIs)	Suicide/Depression
G6PD (rasburicase)	Adverse response to fava beans, neonatal hyperbilirubinemia, Gilbert’s syndrome
IFNL3 (peg interferon)	Variant rs12979860 linked to HCV-induced hepatocellular carcinoma and graft fibrosis, allergic disease in children, liver fibrosis, viral cirrhosis due to HCV, and greater likelihood of HCV persistence, particularly in HCV genotypes 1 and 4. The rs12979860 CC genotype is associated with lower frequency of hepatic steatosis in patients with chronic HCV; carriers of T allele linked to increased susceptibility to chronic hepatitis B virus infection and hepatocellular carcinoma compared with non-carriers
UGT1A1 (atazanavir)	Gilbert syndrome; Crigler-Najjar syndrome type 1; Crigler-Najjar syndrome type 2
VKORC1 (warfarin)	Homozygosity for rare coding mutations in VKORC1 cause combined deficiency of vitamin K dependent clotting factors-2 (VKCFD2)
DPYD (fluoropyrimidines)	Patients homozygous for inactivating variants of DPYD have complete dihydropyrimidine dehydrogenase deficiency
HLA-B*57:01 (abacavir)	HIV viral load; HIV long-term non-progressors
RYR1 (sevoflurane, halothane, enflurane, isoflurane, methoxyflurane, and desflurane, succinylcholine)	Myopathies; central core disease, multiminicore disease, congenital fiber type disproportion, centronuclear myopathy, King-Denborough syndrome, nemaline myopathy, and congenital myopathy with cores and rods