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. 2021 Oct 1;8:697236. doi: 10.3389/fcvm.2021.697236

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Copyright © 2021 Liao, Zhu and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ox-LDL downregulated miR-491-5P and upregulated MMP-9 in THP-1 macrophages. THP-1 macrophages were induced by different concentrations (0, 10, 30, 50, and 70 μg/mL) of ox-LDL. (A) Cell viability was determined using CCK-8. (B,C) qRT-PCR analysis measured MMP-9 level and mir-491-5p level in THP-1 macrophages stimulated with different doses of ox-LDL. Data are presented as the mean ± SD, n = 6. ^*P < 0.05, ^**P < 0.01, and ^***P < 0.001.