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. 2021 Oct 1;8:748118. doi: 10.3389/fnut.2021.748118

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Copyright © 2021 Chen, Zhang, Niu, Mohyuddin, Wen, Bao, Yu, Wu, Hu, Yong, Liu, Abd El-Aty and Ju.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of BTL-1 on the intestinal injury of IBD mouse model induced by DSS. Histopathological changes after DSS stimulation in the colon (A). The in vitro intestinal barrier function evaluated by FITC-D fluorescence intensity (B). Upregulation of BTL-1 on tight junction proteins as determined by qPCR (C–E) and western blotting (F–I). The results were expressed as the means ± SEM of n = 3. ^#P < 0.05, ^##P < 0.01, compared to control group, ^*P < 0.05, ^**P < 0.01 compared to DSS group.