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Exacerbation of seizure score by lack of TRPM8 channels. Mean seizure scores for WT (white: n = 6) and TRPM8KO (black: n = 6) mice, which were at the maximum during 60 min. The results are shown as mean ± SEM; ***p < 0.001, Student’s t-test. TRPM8, transient receptor potential melastatin 8; PTZ, pentylenetetrazol; WT, wild type; SEM, standard error of the mean.
