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. 2021 Oct 1;15:738533. doi: 10.3389/fncel.2021.738533

FIGURE 1.

FIGURE 1

Exogenous irisin treatment increased the expression of BDNF and UCP2 in rats with KA-induced SE. (A,B) The expression of BDNF and UCP2 were detected by western blotting after KA treatment (n = 5 per group). (C–F) Normalized intensity of BDNF and UCP2 relative to GAPDH in the cortex and hippocampus. (G–M) The mean fluorescence intensity of BDNF immunostaining (green) in the left EC after exogenous irisin treatment (n = 5 per group). DAPI, blue. Bar = 50 μm. *P < 0.05, **P < 0.01, and ***P < 0.001, compared with controls; #P < 0.05, ##P < 0.01, and ###P < 0.001 compared with each other (One-way ANOVA with Dunnett’s T3 post hoc test). C, cortex; BDNF, brain-derived neurotrophic factor; EC, entorhinal cortex; H/Hip, hippocampus; UCP2, uncoupling protein 2.