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. 2021 Oct 1;15:738533. doi: 10.3389/fncel.2021.738533

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Copyright © 2021 Cheng, Cui, Zhai, Xin, Yu, Liang, Li and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exogenous irisin treatment reduced the increased mitophagy in rats with KA-induced SE. (A–D) Measurements of LC3B expression in the cortex and hippocampus after irisin administration (n = 5/group). (E–N) Mean fluorescence intensity of LC3B and TOMM20 immunostaining in the DG (n = 5/group). LC3B (red), TOMM20 (green), DAPI (blue). Bar = 30 μm. ***P < 0.001 compared with controls; ^##P < 0.01, and ^###P < 0.001 compared with each other (One-way ANOVA with Dunnett’s T3 post hoc test). C, cortex; H/Hip, hippocampus; LC3B, microtubule-associated protein light chain 3B; TOMM20, translocase of outer mitochondrial membrane 20; DG, dentate gyrus.