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. 2021 Sep 30;24(10):103190. doi: 10.1016/j.isci.2021.103190

Figure 2.

Figure 2

Characteristics of trans- and cis-dimer TROP-2-ECD

(A) The structure of the TROP-2-ECD trans-dimer is shown as cartoon and surface representation, with colors consistent with Figure 3C. The enlarged area shows the details of the interaction interface.

(B) Cartoon representation of bilateral cis-dimer of TROP-2-ECD and the color of subunits are consistent with Figure 3C except for the TY-loop (green).

(C) One subunit in the cis-dimer structure presents a translucent surface format, and the other subunit is the cartoon representation. The enlarged upper right and the bottom left box indicate the main interaction interface of the two subunits containing βC sheet and TY-loop. Residues that participate in hydrogen bond interactions are shown as sticks and labeled. Hydrogen bonds are shown as dashed cyan lines. See also Figure S1, Tables S1, S2 and S3.