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. 2021 Oct 1;11:755814. doi: 10.3389/fonc.2021.755814

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Copyright © 2021 Yu, Zhang, Shao, Liu, Li, Du, Zhang, Zhang, Yuan, Yuan, Liu, Gao, Wang, Hong and Han

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cell division cycle associated 2 (CDCA2) was associated with hepatocellular carcinoma (HCC) prognosis. (A–F) In The Cancer Genome Atlas (TCGA) cases, the impact of TNM stage and CDCA2 on the prognosis of all HCC cases, early HCC cases (TNM stage I/II), and mid- to late-stage HCC cases (TNM stage III/IV) was analyzed by Kaplan-Meier (KM) survival. (G) Forest plot illustrated the hazard ratio (HR) values of CDCA2 and TNM stage by multivariate Cox regression analysis. (H) The nomogram of prognostic 1-, 3-, and 5-year survival rates for HCC was constructed based on CDCA2 expression values [log2 (norm count + 1)] and TNM stage. (I) Receiver operating characteristic (ROC) curve analysis of predictive efficacy of the nomogram model. (J, K) Comparison of mRNA levels and survival analysis of CDCA2 in HCC and paraneoplastic samples originating from Japan in International Cancer Genome Consortium (ICGC) database. ***p < 0.001.