Figure 2.

Comparative analysis of the transcriptional landscape in persistence and extinction TNBC-derived single cells pre-NAC

(A) Hierarchical clustering of TNBC-derived single cells from persistence (n = 534) and extinction (n = 781) group pre-NAC. Each column represents one cell, and each row represents a gene. Expression level of each gene (log2) in a single cell is depicted according to the color scale. (B) Volcano plot illustrating the upregulated (red) and downregulated (blue) genes in the persistence versus extinction group pre-NAC. Validation of top 10 upregulated (C) and top 10 downregulated (D) genes in a second cohort consisting of 782 extinction and 535 persistence TNBC-derived single cells.