Figure 3.

Ingenuity pathway analysis (IPA) of differentially expressed genes in persistence versus extinction group

Enriched canonical pathways based on upregulated (A) and downregulated (B) genes in persistence versus extinction TNBC groups. (C) Tree map (hierarchical heatmap) depicting affected functional categories based on upregulated genes where the major boxes represent a category of diseases and function. Illustration of cellular movement and cell growth and proliferation are shown in the lower panels. (D) Regulator effects network analysis based on IPA highlighting a role for activated (GNA12, PI3K family, IGFBP2, STAT3, and EGFR) and suppressed (COL18A1 and LONP1) upstream regulators and their roles in divining tumorigenic function.