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. 2021 Sep 14;23:151–162. doi: 10.1016/j.omto.2021.09.002

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© 2021 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Targeted depletion of selected persistence-derived genes inhibits TNBC CFU potential in vitro

(A) Expression of BYSL, FDPS, ENO1, MED20, MRPL9, MRPL9, NDUFB11, PMVK, MYC, and GSTP1 in a second cohort of single cells derived from the persistence (782 cells) and the extinction (535 cells) TNBC. (B) Expression of the selected 10 genes in a panel of TNBC cell lines from the CCLE database. Clonogenic potential of MDA-MB-231 (C and D) or BT-549 (E and F) after transfection with the indicated siRNA as single agent or in combination with paclitaxel (PTX; 20 nM). Data are representative of two experiments conducted in duplicate.