Fig. 10.

Structural overview of inhibitors targeting the influenza RdRp. The influenza RdRp is a multifunctional heterotrimer consisting of three subunits: PA, PB1, and PB2. PA encodes the cap snatching endonuclease, PB1 encodes RdRp activity, and PB2 encodes a m⁷G-cap binding activity. The binding sites of inhibitors targeting each subunit and selected residues involved in inhibitor binding and resistance are highlighted. Structures adapted from the following and oriented using PyMol: FluA-polymerase heterotrimer 4WSB [251], PA endo with Baloxavir, 6FS6 [261], PB2 with pimodivir 4P1U [273]. Structural snapshots for favipiravir and molnupiravir are not shown as structures of the polymerase bound to these molecules are currently unavailable.