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Differences in cytokine inhibition by PD‐1 are associated with functional heterogeneity. (a) Secreted levels of IL‐2 and IL‐15 from primary human CD4+ T cells stimulated with anti‐CD3 and anti‐CD28 with or without PDL2 quantified by Luminex. (b) Heatmaps displaying DEG between proliferating and non‐proliferating cells stimulated with anti‐CD3, anti‐CD28, and PDL1 or PDL2. Thresholds are set at log2 fold change ±1, and significant DEG with adjusted P‐value 0·02 are indicated by *
