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. 2021 Sep 25;24(10):103173. doi: 10.1016/j.isci.2021.103173

Figure 6.

Figure 6

Proposed model for the mechanism of SLFN11 induction in GOF mutant leukemic cells

(A) In leukemic cells with GOF mutation in JAKs, JAKs are auto-phosphorylated without IFN stimulation. These cells promote phosphorylation of AKT while the activation of AKT may suppress the activity of ERK. Both of AKT and ERK induce SLFN11 expression via ETS family proteins.

(B) In leukemic cells with wild-type JAKs, SLFN11, and classical IFN stimulated genes can be induced in response to exogenous IFNs by the classical IFN-JAK-STATs signaling pathway.